DELAYED CUTANEOUS MANIFESTATIONS IN PATIENTS WITH COVID-19 CAUSED BY SARS-COV-2. CLINICAL OBSERVATIONS IN THE RUSSIAN FAR EAST

Chung M. K., Zidar D. A., Bristow M. R., et al. (2021) warn that a historic pandemic due to the coronavirus disease, COVID-19, could have negative potential consequences for the cardiovascular system for millions of survivors worldwide [1]. At the present stage, mechanisms of the long-term consequences of COVID-19 disease caused by SARS-COV-2 are not studied well;any assumptions regarding to the consequences of SARS-Cov-2 are hypothetical. Therefore, long-term effects require indepth research in the dynamics of recovery process after severe infections and rehabilitation of survivors. This will facilitate and increase the effectiveness of the treatment protocol for this disease and its complications [2]. The duration of the incubation period of the disease, the presence of sometimes not expressed or absent symptoms makes identification of the disease caused by SARS-CoV-2, COVID-19 infection, in some cases, too complicated [3]. The duration of the rehabilitation time, the complexity of pathogenetically based treatment do not yet have comprehensive information, therefore, it is difficult to resolve the issue of the timing of vaccination of patients who have recovered from COVID-19 infection. All the data obtained for each case of the disease, depending on age, the presence of concomitant diseases and individual terms of health recovery with the characteristics of complications in the late periods after recovery, has high relevance and great importance [4]. According to Wu Y., Guo C., Tang L., (2020), the excretions of recovered patients remains dangerous for others around 5 weeks after clinical recovery [5]. At the moment, there is practically no exact information about the duration and intensity of immunity in an infection caused by SARS-CoV-2 [6]. To develop protocols of COVID-19 treatment, principles and paradigms for the development of alternative effective vaccines for the prevention COVID-19 affects the health of consumers of the vaccine, which requires long-term monitoring in the post-recovery.

THE MECHANISM OF BLOOD COAGULATION IN COVID-19 PATHOGENESIS

One of the formidable complications of SARS-COV-2 infection leading to death is coagulopathy. The mechanisms of the development of this pathology at the present stage have not been studied, and clinical blood tests indicate that against the background of normal blood clotting indices, only the Ddi-D-dimer protein exceeds the norm many times over. The aim of the study was to study and analyze biochemical parameters in patients of Primorsky Region (Russia) infected with SARS-COV-2 against the background of concomitant vascular pathology and the development of DIC syndrome. The authors came to the conclusion about the existence of two mechanisms of circulatory disorders in the vessels of the microvasculature, associated with the violation of the integrity of the vascular wall and destruction of erythrocytes. Further research is needed to study the mechanisms of SARS-CoV-2 aggression, leading to thrombotic complications.